TNFSF10 and AIDS: Documented immune differences include differential induction of type I IFN and IFN-stimulated genes (ISGs) such as TNF-related apoptosis inducing ligand (TRAIL), as well as the immune regulators cytotoxic T-lymphocyte antigen-4 (CTLA-4) and indoleamine 2,3-dioxygenase (IDO), all of which contribute to T cell dysfunction and potentially the development of AIDS [5]–[12].