Intense research over the last several decades has partially redressed this situation and there are now many new and emerging classes of anti-hyperglycemia agents including, incretin mimetics, dipeptidyl peptidase (DDP)-4 inhibitors, sodium glucose co-transport 2 inhibitors and in the current context, glucokinase activators (GKAs) [7-9]. This evidence concerns the gene GCK and Hyperglycemia.