CDH1 and gastric cancer: p53, famous for its tumor-suppressing role, has a mutated rate ranging from 0 to 21% in diffuse type GC and 36–43% in intestinal type GC [11]; E-cadherin, which plays a pivotal role in EMT (Epithelial Mesenchymal Transition), is predisposed to mutagenesis in sporadic diffuse type GC (33–50%) [12]; another star gene harboring high correlation with gastric cancer is RNUX3, which manifests to be a tumor-suppressor gene of GC [13].