In sepsis group, the mean value of serum IL-8 in patients with IL-8 (-251A/T) mutant allele was 694.333 ± 64.278 pg/mL which is significantly higher in comparison to mean value in patients with wild gene which is 364.2 ± 143.421 pg/mL (P < 0.001). The gene discussed is CXCL8; the disease is Sepsis.