CXCL8 and systemic inflammatory response syndrome: In SIRS patients, the mean value of IL-8 in patients with IL-8 (-251A/T) mutant allele was 227.308 ± 43.235 pg/mL which was significantly higher in comparison to mean value in patients with wild gene which was 173.701 ± 31.762 pg/mL (P < 0.001) (Table 6).