PCSK1 and hematoma: Although the mechanism(s) whereby Nec-1 limited neurological injury were not explored in this study, it is notable that the biologically inactive, structural analog of Nec-1 did not exert the same protective effects of Nec-1 with respect to BBB opening, edema development, and behavioral outcomes; however, it is noteworthy that Nec-1inactive attenuated hematoma volume to a similar magnitude as compared to Nec-1.