Therefore, systemic release of various promoters of inflammation, such as increased reactive oxygen species, TNF-α, TGF-β, plasminogen activator inhibitor-1, C-reactive protein (CRP), and IL-6, produced by hepatocytes and nonparenchymal cells, including Kupffer cells and hepatic stellate cells, can be possible mediators that link NAFLD and CKD. Here, CRP is linked to chronic kidney disease.