APOE and atherosclerosis: Second, we constructed lentiviral vectors, which can efficiently deliver small interfering RNAs (siRNAs) due to their stable transduction of both dividing and nondividing cells, and aimed at knocking down CHI3L1 to explore the mechanisms of CHI3L1 in atherosclerosis in apolipoprotein E-knockout (ApoE−/−) mice as a potential target for treatment.