In fact, total bilirubin levels have been reported to be elevated, probably due to an increase in stress-induced HO-1 activity after acute myocardial infarction [29], and total bilirubin levels are positively associated with the severity of coronary artery disease in patients with both STEMI [30], and non-STEMI [31]. The gene discussed is HMOX1; the disease is coronary artery disorder.