Comparing the secretome of colon CSCs with that of more differentiated colon cancer cells in the bulk tumor they found that CSCs secreted much higher levels of aldehyde dehydrogenase family 1, member A1 (ALDH1A1) and bleomycin hydrolase (BLMH), two enzymes able to detoxify chemotherapeutics. The gene discussed is ALDH1A1; the disease is malignant colon neoplasm.