Comparing the secretome of colon CSCs with that of more differentiated colon cancer cells in the bulk tumor they found that CSCs secreted much higher levels of aldehyde dehydrogenase family 1, member A1 (ALDH1A1) and bleomycin hydrolase (BLMH), two enzymes able to detoxify chemotherapeutics. Here, ALDH1A1 is linked to colonic neoplasm.