Here, we investigated the molecular mechanisms involved in TGF-β-induced WNT-5A expression using airway smooth muscle cells as 1] airway smooth muscle cells are key structural and functional component of airways and major contributor of airway remodeling in asthma and 2] TGF-β upregulates WNT-5A expression in these cells. The gene discussed is TGFB1; the disease is asthma.