TP53 and cancer: Four, TP53 c.215C>G (p.Pro72Arg) [41], BRCA1 c.2612C>T (p.Pro871Leu) [42], ERBB2 c.3508C>G (p.Pro1170Ala) [43], and FLT3 c.680C>T (p.Thr227Met) [44], [45] have been linked to the development of cancer or to treatment response.