PPARG and obesity due to melanocortin 4 receptor deficiency: The hypothesis that BLyS might be a beneficial factor in metabolic inflammation in human obesity is further supported by the data of an independent research group, showing that BLyS expression, like PPAR-γ expression, is induced during 3T3-L1 adipogenesis [13], supposing a positive but not a negative effect in human adipose tissue biology.