TLR4 and obesity due to melanocortin 4 receptor deficiency: In this inflammatory feature associated with obesity and insulin resistance, researchers of several parts of the world have been investigating the role of physical exercise to restore insulin sensibility, reduce activating of TLR4, serine-kinase proteins JNK and IKKβ in obese animals.(3) Oliveira et al.(3) observed that suppression of inflammatory pathway lasted for 24 and 36 hours after the last bout of exercise.