However, it is unknown whether and how these factors work together to regulate cardiac hypertrophy, whether ATG9A mediated autophagic activity is excessively activated in Ang II induced cardiomyocyte hypertrophy, and whether miR-34a can modulate Ang II-induced cardiomyocyte hypertrophy by targeting ATG9A expression. This evidence concerns the gene ATG9A and cardiac hypertrophy.