Indeed, Chakraverty et al [77] reported that among 235 patients admitted to an adult intensive care unit, clinical coagulopathy, defined as bleeding unexplained by local or surgical factors, was identified in 13.6% of patients; moreover, a prothrombin time (PT) difference > or  = 1.5 was found in 66% of patients and a platelet count <100×109/L in 38% of patients. This evidence concerns the gene F2 and blood coagulation disease.