FOXP3 and Abnormal intestine morphology: The etiological role of gliadin in T1D is supported by the study by Galipeau HJ et al. [50] documenting that while sensitization with gliadin induces only moderate enteropathy in humanized NOD-DQ8 mice, when combined with partial antibody depletion of Foxp3 Tregs it led to development of insulitis.