It has been shown that in the neonatal thymectomy NOD model of T1D, gut intraepithelial CD8+γδ T cells can prevent development of diabetes, and proper development of intraepithelial γδ T cells is required for induction of regulatory CD4+CD25+ T cells by oral insulin [32]. This evidence concerns the gene INS and dentatorubral-pallidoluysian atrophy.