In a Cox proportional hazards analysis, a lower than the mean rate of insulin-stimulated non-oxidative glucose disposal at baseline also predicted a higher risk for developing type 2 diabetes than a rate above the mean (HRR 2.5, 95% CI 1.4, 4.5, p = 0.002, adjusted for age, sex, percentage body fat, AIR and glucose oxidation rate; data not shown). The gene discussed is INS; the disease is type 2 diabetes mellitus.