Of these 287 individuals with NGT who had measures of carbohydrate oxidation rate during insulin stimulation at baseline (baseline age 26.4 ± 6.0 years) and also had follow-up data for development of diabetes (follow-up time 7.8 ± 8.2 years), 99 (34%) developed type 2 diabetes. The gene discussed is INS; the disease is type 2 diabetes mellitus.