Our study confirms that WISP-1 plays an important role in FIR-induced radioresistance in esophageal carcinoma cells, as the expression of WISP-1 correlated with the development of radioresistance in these cells, and radioresitance was induced by the presence of recombinant WISP-1 in medium. This evidence concerns the gene CCN4 and carcinoma of esophagus.