PCGEM1 and Familial prostate cancer: Lastly, we are unconvinced that the K349Me, K631Ac, or K634Ac AR PTMs represent a plausible mechanism for interaction between AR and PCGEM1 and PRNCR1. While our results challenge the notion that PCGEM1 and PRNCR1 play a causal role in prostate cancer, we regard lncRNAs as an emerging field of study in cancer [3, 6, 20, 21] and we are encouraged by the interest in lncRNAs in prostate cancer.