In specific, we sought to reproduce three core observations suggested by Yang et al published in Nature (see [1]) and include: 1) that PRNCR1 and PCGEM1 are highly overexpressed in aggressive forms of prostate cancer, 2) that these two lncRNAs bind to AR under ligand-stimulated conditions, and 3) that the coordination of PRNCR1 and PCGEM1 interact with AR via specific post-translational modifications of the AR protein. This evidence concerns the gene AR and Familial prostate cancer.