PRRT2 and neoplasm: PKCɛ is overexpressed in various tumor types [16] and is associated with different processes related to cancer development namely, cell transformation, cell survival, cell proliferation, EMT, cytoskeletal reorganization, extracellular matrix (ECM) rearrangement, disruption of cell-cell contacts, cell motility, stem cell properties and therapy resistance [16,19,21,22].