DDIT3 and McLeod neuroacanthocytosis syndrome: MLS are characterized by a translocation that fuses the DDIT3 (CHOP) gene on chromosome 12q13 with the FUS (TLS) gene on chromosome 16p11 in approximately 90% of cases, or the DDIT3 (CHOP) with the EWSR1 on chromosome 22q12 in the remaining cases [42].