AICDA and B-cell chronic lymphocytic leukemia: The study of the mutational pattern in the IGHV gene in CLL patients showed characteristics of somatic hypermutation (SHM), including less replacement (R) mutations in framework (FR) compared with CDRs of IGHV genes, excess of transitions over transversions and mutations targeting specific nucleotides or nucleotide motifs specific of AID (RGYW) and polymerases (WA) [8,15,16].