Alternatively to its potential direct impact on tumor progression, STAT1 expression and activation might serve as markers for chronic or acute inflammatory processes in the tumor, which are known to potentially influence the progress of disease depending on the type of infiltrating cells and tumor subtypes [21,22]: this is because IFNs, the major triggers of STAT1 expression and activation in the tumor epithelium and stroma, are secreted during acute as well as chronic inflammatory responses [23]. Here, STAT1 is linked to neoplasm.