Furthermore, by increasing hypoxic cell survival αB-crystallin may also decrease the sensitivity of a tumor to cancer treatments, such as radiation or other cancer treatments, as shown by the effect of αB-crystallin on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) as well as cisplatin-induced apoptosis in human ovarian cancer cells [56]. This evidence concerns the gene TNFSF10 and ovarian cancer.