MMP9 and neoplasm: Rajapakse et al. [100] reported in their study that CCOS exerted a dose- dependent inhibitory effect on MMP-9 in human fibrosarcoma cell line (HT1080); they observed that reduction in MMP-9 expression was due to downregulation of MMP-9 transcription that was mediated via inhibition of AP-1 (activator protein-1) and this inhibition of MMP-9 expression led to inhibition of tumor invasiveness.