CDKN2A and acute lymphoblastic leukemia: In most clinical studies that have assessed the prognostic significance of CDKN2A/B loss of function in ALL, CDKN2A/B deletion or hypermethylation do not appear to be associated with changes in outcome for pediatric ALL, while silencing or inactivation of the locus predicts a worse outcome in adults (99, 136, 138, 142–146).