This was remarkably different from only about 50 DMRs identified in CRLF2-rearranged ALL samples, many of which were “Ph-like” ALL samples that share a major transcriptional program with Ph+ ALL but are negative for the BCR–ABL1 translocation, and instead commonly have activating Jak1/2 mutations. The gene discussed is CRLF2; the disease is acute lymphoblastic leukemia.