IKZF1 and leukemia: Gene-expression profiling suggests that IKAROS mutated B-ALL has a more prominent “stem-cell signature” (99, 115), and a larger leukemia initiating cell pool [LIC, defined by CD34 expression rather than functionally (96)], suggesting that some of the functions of Ikaros in silencing stem-cell programs in HSCs may play a role (105, 116).