PTGS2 and cardiovascular disorder: In response to inflammatory stimuli, bacterial lipopolysaccharide (LPS), activates SMCs to induce the expression of proinflammatory mediators, including inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), which are responsible for the induction of nitric oxide (NO) and prostaglandin E2 (PGE2), respectively, and are known to promote SMC injury and cardiovascular diseases [2, 3].