MAPK8 and cancer: While investigating the underlying proapoptotic mechanisms of ZJW extracts on DDP-induced apoptosis in SGC-7901/DDP cells, we found that the synergistic effect of ZJW extracts on proapoptosis of DDP in SGC-7901/DDP cells might be dependent on the activation of JNK, which played vital role in the development of cancer [20, 21].