BCL2 and gastric cancer: In conclusion, noncytotoxic ZJW extracts could enhance the proapoptotic effect of DDP in human gastric cancer SGC-7901/DDP cells through increasing the intracellular accumulation of DDP, which promoted the activation of JNK, followed by the promotion of Bcl-2 and inhibition of Bax, further increased release of Cytochrome C from mitochondria to cytoplasm, and finally the activation of caspase cade reaction.