While an imbalanced Th1/Th2 immune response is linked to certain hypersensitivity disorders such as allergy, asthma, and hay fever [12], studies have suggested that using biological response modifier (BRM) to restore the balance between Th1 and Th2 immune response can be a potential treatment option for the IgE dependent hypersensitivity [13]. Here, IGHE is linked to allergic disease.