Both physiologically based (hyperoxygenation, hypothermia, avoidance of hyperthermia and hyperglycemia, hypertension, hemodilution, and hypervolaemia) and pharmacologically based (antifibrinolytic drugs, calcium antagonists, anesthetics, magnesium, erythropoietin, and others) therapies have been explored [58, 59]. The gene discussed is EPO; the disease is Hyperglycemia.