BACE1 and early-onset autosomal dominant Alzheimer disease: This is exemplified by the upregulation of a non-coding antisense homologue of the beta-secretase BACE1 (BACE1-AS) that acts as BACE1 ceRNA and concomitantly increases Bace1 mRNA stability and leads to augmented deposition of Aβ-plaques in Alzheimer’s disease (AD; Faghihi et al., 2008, 2010).