Genetic data being considered for return to participants include SNPs of medical or pharmacogenetic relevance, genetic risk scores for common diseases as well as pharmacogenomic variants, and clinically actionable incidental findings related to next-generation sequencing of 84 VIPs (e.g., RYR1 and CACNA1S genes associated with malignant hyperthermia). The gene discussed is RYR1; the disease is Malignant hyperthermia.