Pathogenic variants in CACNA1C and RYR1 (malignant hyperthermia), KCNH2 and SCN5A (long QT syndrome), RYR2 (catecholaminergic polymorphic ventricular tachycardia), and LDLR (hyperlipidemia). Here, RYR1 is linked to catecholaminergic polymorphic ventricular tachycardia.