RYR1 and Prolonged QT interval: These variants include risk alleles in CACNA1C (malignant hyperthermia), RYR1 (malignant hyperthermia), KCNH2 (long QT syndrome), SCN5A (long QT syndrome), RYR2 (catecholaminergic polymorphic ventricular tachycardia), and LDLR (hyperlipidemia).