These variants include risk alleles in CACNA1C (malignant hyperthermia), RYR1 (malignant hyperthermia), KCNH2 (long QT syndrome), SCN5A (long QT syndrome), RYR2 (catecholaminergic polymorphic ventricular tachycardia), and LDLR (hyperlipidemia). This evidence concerns the gene CACNA1C and catecholaminergic polymorphic ventricular tachycardia.