Based on this criterion, homozygosity of single nucleotide polymorphism (SNP) rs6025 (R506Q, also known as the Factor V Leiden mutation) and rs1800562 (HFE C282Y, associated with hereditary hemochromatosis) were judged to have the highest clinical relevance (Fullerton et al., 2012). This evidence concerns the gene F5 and hereditary hemochromatosis.