EIF4E and infection: Among the proposed roles for eIF4E/(iso)4E in potyvirus infection are (i) recruitment of the translation initiation apparatus for vRNA translation, (ii) PD targeting of vRNA via VPg, eIF4E, CI, and eIF4G, and (iii) safeguarding virus translation/replication in the cytoplasm via an eIF4E, P1, VPg, and HC-Pro silencing suppressor complex (as reviewed in Wang and Krishnaswamy, 2012).