Thus, IL-4, mainly produced by intra-tumoral CD4+ Th2 cells, modulates the TAM phenotype and induces them to secrete EGF, leading to EGF-R-dependent invasion and metastasis (108), as well as cathepsins B and S, shown to be critical for promoting tumor growth, angiogenesis, and invasiveness in several tumor models (109). This evidence concerns the gene EGF and neoplasm.