The anti-inflammatory cytokines TGFβ and IL-10 are produced by neoplastic cells, tumor fibroblasts, and tumor-infiltrating Treg and both cytokines activate the Stat3 pathway, leading to the expression of genes associated to an M2 phenotype, such as IL-10, Tgfb1, Mrc1 (65, 112, 121). This evidence concerns the gene IL10 and neoplasm.