In established HCC tumors from patients, CD68+ monocytes/macrophages were amongst the most abundant inflammatory cells, comprising two main subpopulations: small HLA-DRhigh IL-10low cells in peritumoral stroma, reminiscent of newly recruited monocytes, and larger HLA-DRlow IL-10high cells in cancer nests resembling mature macrophages (23). Here, CD68 is linked to cancer.