TFF2 and neoplasm: Some of these are: CDH1 that codes for E-cadherin, a transmembrane glycoprotein involved in maintaining epithelial integrity (Chan et al., 2003); GATA4 and GATA5 encoding transcription factors (Wen et al., 2010); and TFF2 (encoding trefoil factor 2) (Peterson et al., 2010) and FOXD3 (encoding a forkhead box transcriptional regulator) that are tumor suppressors (Cheng et al., 2013).