HMGA2-induced EMT is promoted by TGF-β signaling (147) and the pro-inflammatory cytokine oncostatin M (OSM) (148) which signal via the STAT3 (148), the Ras/MAPK signaling pathway (135), and Twist and Snail, the two key regulators of EMT and major contributors to metastasis and tumor recurrence (104, 149). The gene discussed is HMGA2; the disease is neoplasm.