XRCC3 and thyroid cancer: Two other studies identified the combinations of RAD52 2259C > T, XRCC2 R188H and XRCC3 T241M polymorphisms (37) and RAD51 Exon1/59G > T, XRCC3 Thr241Met variant alleles to have predictive value for the polygenic risk of thyroid cancer (19).