DNA damage elicited by perinatal asphyxia implies PARP-1 overactivation, promoting NF-κB translocation and expression of proinflammatory cytokines (Ullrich et al., 2001), a phenomenon associated with microglial migration toward the site of neuronal injury (see Skaper, 2003; Gagne et al., 2008). Here, PARP1 is linked to perinatal asphyxia.