Firstly, unconditional logistic regression analysis was utilized to detect associations between five ADH1B-ADH1C-ADH7 cluster SNPs (rs1042026, rs17033, rs1614972, rs1789903 and rs17028973) and ESCC risk in Hangzhou discovery set (Table 2). The gene discussed is ADH1B; the disease is esophageal squamous cell carcinoma.