There have been two previous analyses of mucin expression in SBC tissues in 30 cases by Zang et al. [13] and in 23 cases by Lee et al. [14] In the present study of 60 cases, we found that increased expression of MUC1, MUC5AC and MUC16 in SBCs was related to poor prognostic factors such as deeper invasion, venous invasion, lymph node metastasis, and cases in which only non-curative resection was possible. The gene discussed is MUC16; the disease is metastatic malignant neoplasm in the lymph nodes.