Trial NCT01336634 examines BRAF inhibitor dabrafenib/GSK2118436 in BRAF-mutant NSCLC, and preliminary results suggest a promising clinical activity in pretreated patients with stage IV NSCLC carrying BRAFV600E mutation (overall response rate of 60%, BRF113928). The gene discussed is BRAF; the disease is non-small cell lung carcinoma.