SMAD4 and neoplasm: We did not observe a correlation between the expression of SRC-3, ErbB-2, hTERT, PTEN, FoxO1, Bcl-2, SMAD4, c-myc, Hsp70, Hsp90 and CHIP expression in BxPC-3 cells (Figure 1A), this result could be explained by feedback of complicated signaling network in different tumor environments.