STUB1 and familial pancreatic carcinoma: In addition, the expression of CHIP in pancreatic cancer tissues was significantly reduced compared to matched normal tissues without inflammatory cellular infiltration (p<.01) (Table II), while there was no significant difference between pancreatic cancer tissues and paired non-cancerous tissues infiltrated with inflammatory cells (P=0.558) (Table III), which suggests that inflammation could affect the expression of CHIP in pancreatic tissues.