STAT3 and neoplasm: The heterogeneous nature of PCa tumors combined with the multifaceted roles of STAT3 in survival and activation pathways in tumor cells, stromal cells and immune cells may answer why there is such diversity in effects of STAT3 inhibitors in patient responses; certainly future explorations will entail targeted combination therapy of STAT3 inhibition with other key pathways identified in individual patient tumors that have actionable targets.