STAT3 and posterior cortical atrophy: Moreover, treatment of Du145 PCa that are positive for aldehyde dehydrogenase (ALDH), a marker of CSCs which express high levels of phosphorylated STAT3 with the potent and specific STAT3 inhibitor galiellalactone, reduces frequency of ALDH+ cells and induces apoptosis of Du145-ALDH+ cells [61].