Taken together, it is clear that STAT3 sits at the crossroads of multiple signalling pathways that are essential for the progression of PCa to advanced disease and uncovering specific mechanisms of action of STAT3 in PCa tumor cells, stromal cells and associated hematopoietic cells will bring the PCa community closer to exploring STAT3 as a therapeutic target. Here, STAT3 is linked to posterior cortical atrophy.