Therefore, as shown in our results, EMT also can be induced by activation of TGFβ signal pathway to result in drug resistance and metastasis in NSCLC, and inhibition of TGFβR2 by miRNA 17 family can interdict EMT to enhanced chemotherapy sensitivity and metastasis inhibition of NSCLC (Figure 5). The gene discussed is TGFB1; the disease is non-small cell lung carcinoma.