CYGB and cancer: Nevertheless, 1) based on the assumption that, similar to other globins, CYGB could have a specific function in limited tissues or cell types, and 2) according to our initial aim to assess the correlation between CYGB loss and the resultant tumor malignancy, we sought to perform an extensive screening for CYGB expression in several cancer cell lines and found that several, but not all, melanoma cell lines highly expressed CYGB.