Analyses of a small sample (32 miscellaneous types of NHL, no DLBCLs analyzed) showed promoter hypermethylation primarily in NK/T-cell NHL [43], and a second study showed that miR34A is downregulated by promoter hypermethylation (4 of 7 analyzed DLBCLs) and/or MYC overexpression during the transformation of gastric MALT type lymphoma to aggressive gastric DLBCL [21]. The gene discussed is MYC; the disease is non-Hodgkin lymphoma.