Breaking down the methylation results by the WHO grade, 6 cases (9.68%) belonged to WHO grade I, 7 cases (20%) to WHO grade II and 1 case (12.5%) to the anaplastic meningioma grade III (Table 1).There was an increasing rate of TIMP3 hypermethylation from grade I (9.68%) to grade II (20%). This evidence concerns the gene TIMP3 and meningioma.