To evaluate the anti-inflammatory effects of MPT0G009, supernatants from cultures of RAW264.7 cells (Figure 1b) and RA fibroblast-like synoviocyte (RA-FLS; Figure 1c) were incubated with different concentrations of MPT0G009 (0, 0.1, 1 or 10 μM) or SAHA (0, 0.3, 3 or 30 μM) for 30 min before and during incubation for 24 h with lipopolysaccharide (LPS, 25 ng/ml) or IL-1β (10 ng/ml). The gene discussed is IL1B; the disease is rheumatoid arthritis.