Signal transducer and activator of transcription 3 (STAT3) is inappropriately activated in various tumor types, such as lymphoma, breast, ovarian, pancreatic, and lung cancer, and is particularly activated in aggressive and invasive tumors.13, 14 STAT3 is a transcription factor that translocates into the nucleus, binding to its responsive element after activation. This evidence concerns the gene STAT3 and lung carcinoma.