STAT3 and neoplasm: It was found that microtubule-targeting agents decrease the tyrosine phosphorylation-induced activation of STAT3 (Tyr705) in tumor cells, inhibit the expression of STAT3 target genes, and correlate with its cytotoxic effect.38, 39, 40 In our study, we found that MPT0B271 specifically reduced STAT3 phosphorylation at Tyr705.