Pathway analysis indicated that these co-regulated genes were mainly involved in the calcium signaling pathway, cardiomyopathy related pathways, and cancer related pathways (Fig 4C and 4D), such as VEGF, an angiogenic factor, and VEGF-activated signaling component, including Ras, Akt and MAPK family members, decreased in the MI group, but significantly increased in the EA group (Table 1). Here, AKT1 is linked to cardiomyopathy.