For example, the splicing patterns of ADD3, EXOC1, MYO18A, NFYA, and NUMB were changed in 4 pairs of adenocarcinoma (A1-4#) and 4 pairs of squamous cell carcinoma tissues (S1-4#), in which the expression levels of QKI are significantly reduced in tumor tissues compared to the adjacent normal tissues. The gene discussed is EXOC1; the disease is squamous cell carcinoma.